Nanotoxicology, Immunotoxicology and Biodistribution
Infrastructure and services to study nanotoxicology, immunotoxicology and biodistribution of materials designed for biological applications.

The Nanotoxicology and Immunotoxicology Unit (UNATI) of IIS Aragón offers to companies, research centers and other professionals, a specialized service of pharmacological and toxicological analysis, customized to their needs, to confirm the safety of their products, offering a high added value and a very positive impact at the time of commercialization.
The toxicological studies carried out will be based on the recommendations, regulations and protocols published by international agencies, specifically the protocols of the Organization for Economic Co-operation and Development (OECD). The portfolio of services offered includes both in vitro and in vivo studies (C. elegans, Mus musculus and Rattus norvegicus). UNATI also extends its services, beyond nanomaterials, to any company and research group interested in increasing the quality of products for human use, whether of synthetic or natural origin, individualized or in their final formulation.

Principal Investigator: Julián Pardo Jimeno
Technician in charge: Ariel Ramirez Labrada

Investigador Principal Investigator: Julián Pardo Jimeno
Technical Manager: Ariel Ramirez Labrada
Contact: unati@iisaragon.es
Web: https://www.iisaragon.es/nuestros-servicios/servicios-de-apoyo-comun/#UNATI

It offers support to researchers working with animal models of human disease or human specimens for biomedical research by providing a wide range of histopathological techniques, as well as assistance in the selection of appropriate methods of sample collection and preservation until processing.
It has the technical means and expertise to perform the techniques that comprise the processing of animal and human samples for biomedical research, including carving, kerosene embedding and OCT, as well as routine and special staining techniques.
Immunohistochemical characterization of samples, antibody development for immunohistochemical staining and laser microdissection are also offered.
The service has specialized equipment for the processing of resin-embedded materials (implants, biomaterials, bone) by means of the EXAKT band saw and polishing system.

Laboratory technician: Cindy Giraldo Jiménez
Contact: cgiraldo.iacs@aragon.es
Web: https://www.iacs.es/servicios/servicios-cientifico-tecnicos/anatomia-patologica/

Simultaneously detecting and measuring multiple iron species in biological materials is difficult. No universally accepted method has been established for magnetic nanoparticle studies in biomedical applications, so multiple techniques are usually combined. At INMA, we have developed a way to track and quantify magnetic nanoparticles in biological samples using AC magnetic susceptibility measurements.
In addition to detecting magnetic nanoparticles in biological samples, this type of analysis can also quantify other iron-containing substances, such as ferritin. The method requires minimal sample preparation and can analyze large amounts of tissue (up to hundreds of milligrams). The specificity of the magnetic measurements allows monitoring of changes in the nanoparticles (e.g. aggregation, dissolution, etc.), and the high sensitivity of the equipment leads to low detection limits for iron species. In summary, this is a very valuable tool for monitoring magnetic iron oxide nanoparticles in biological samples.

For more info: Y. Fernández-Afonso, et al. Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin,and Other Iron-Containing Species. ACS Appl. Bio Mater. 2022, 5, 5, 1879-1889.

Contact: Lucía Gutierrez (lu@unizar.es)

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