Instituto de Nanociencia y Materiales de Aragón
  • EspañolEspañol
Intranet
  • THE INSTITUTE
    • General information
      • Welcome
      • History of the Institute
      • Organizational chart
      • Departments
        • Department 1: Functional organic materials
        • Department 2: Materials for energy and environment
        • Department 3: Physics of materials and nanosystems
        • Department 4: Bio-nano-medicine
        • Department 5: Multifunctional magnetic materials
      • Scientific Committee
      • Annual Reports
      • Welcome Handbook
      • Associations
    • Directory
    • Location and contact
  • RESEARCH
    • Research Areas
      • Area 1: Materials for energy
        and environment (MEM)
      • Area 2: Materials for biomedicine (BIO)
      • Area 3: Materials for information
        technology (MTI)
      • Area 4: New phenomena at the
        nanoscale (NFN)
      • Area 5: Synthesis, processing and scaling
        of advanced functional materials (SPE)
      • Area 6: Singular experimental
        technologies (TES)
    • Research Groups
    • Scientific publications
    • International projects
    • INMA scientific infrastructure
    • Microdevices Engineering Technical Unit (UTIM)
      • Structure UTIM
      • Catalog UTIM
      • Applications UTIM
    • INMA large scientific facilities
  • TRAINING
    • Master NANOMAT
    • Degree studies
    • Master studies
    • PhD studies
    • Internships
    • Scholarships and grants
    • Course of introduction to laboratory safety -SegurINMA
    • Research career path in Spain
  • JOB OFFERS
  • DISSEMINATION
    • Activities
      • General public
      • Schools and institutes
      • Special events
        • Researchers’ Night
        • Woman and science
        • Semana de la Ciencia
          Valle de Benasque
      • Cátedra SAMCA de Nanotecnología (EN)
      • LMA
    • Projects
    • Advising and training
    • Awards and distinctions
    • Multimedia
  • TRANSFER
    • Technological offer
      • Patents
      • Capabilities for industry
    • Transferred technology
    • Spin-offs
  • EQUALITY
    • Protocols and prevention against harassment
Instituto de Nanociencia y Materiales de Aragón
  • THE INSTITUTE
    • General information
      • Welcome
      • History of the Institute
      • Organizational chart
      • Departments
        • Department 1: Functional organic materials
        • Department 2: Materials for energy and environment
        • Department 3: Physics of materials and nanosystems
        • Department 4: Bio-nano-medicine
        • Department 5: Multifunctional magnetic materials
      • Scientific Committee
      • Annual Reports
      • Welcome Handbook
      • Associations
    • Directory
    • Location and contact
  • RESEARCH
    • Research Areas
      • Area 1: Materials for energy
        and environment (MEM)
      • Area 2: Materials for biomedicine (BIO)
      • Area 3: Materials for information
        technology (MTI)
      • Area 4: New phenomena at the
        nanoscale (NFN)
      • Area 5: Synthesis, processing and scaling
        of advanced functional materials (SPE)
      • Area 6: Singular experimental
        technologies (TES)
    • Research Groups
    • Scientific publications
    • International projects
    • INMA scientific infrastructure
    • Microdevices Engineering Technical Unit (UTIM)
      • Structure UTIM
      • Catalog UTIM
      • Applications UTIM
    • INMA large scientific facilities
  • TRAINING
    • Master NANOMAT
    • Degree studies
    • Master studies
    • PhD studies
    • Internships
    • Scholarships and grants
    • Course of introduction to laboratory safety -SegurINMA
    • Research career path in Spain
  • JOB OFFERS
  • DISSEMINATION
    • Activities
      • General public
      • Schools and institutes
      • Special events
        • Researchers’ Night
        • Woman and science
        • Semana de la Ciencia
          Valle de Benasque
      • Cátedra SAMCA de Nanotecnología (EN)
      • LMA
    • Projects
    • Advising and training
    • Awards and distinctions
    • Multimedia
  • TRANSFER
    • Technological offer
      • Patents
      • Capabilities for industry
    • Transferred technology
    • Spin-offs
  • EQUALITY
    • Protocols and prevention against harassment
Instituto de Nanociencia y Materiales de Aragón
No Result
View All Result

Home » DNABEATS R&D&I project, which seeks to boost cardiac regeneration after myocardial infarction using cutting-edge nanotechnology, gets underway

DNABEATS R&D&I project, which seeks to boost cardiac regeneration after myocardial infarction using cutting-edge nanotechnology, gets underway

by INMAweb
18/09/2023
in News
0
DNABEATS R&D&I project, which seeks to boost cardiac regeneration after myocardial infarction using cutting-edge nanotechnology, gets underway

The DNABEATS R&D&I project, which seeks to boost cardiac regeneration after myocardial infarction using cutting-edge nanotechnology, gets underway

Research work has begun on the DNABEATS project, which aims to develop advanced technology to boost cardiac regeneration using DNA nanotechnology and gene therapy. The project is endowed with 700,000 euros and has a duration of 3 years. DNABEATS is led by Silvia Hernández Ainsa, ARAID researcher at the University of Zaragoza at the Aragon Nanoscience and Materials Institute (INMA), a joint institute of the CSIC and the University of Zaragoza. In addition, IIS Aragón is also participating in the project, together with other entities from four European countries.

Heart disease, in particular myocardial infarction and its evolution towards heart failure, is one of the leading causes of death worldwide. In Spain, the prevalence of heart failure is around 2% of the adult population (age 18), affecting around 8% of people over 80. It is a health problem associated with ageing. Current treatments are insufficient to address this problem, and heart transplantation remains the only solution for heart failure. DNABEATS aims to develop advanced materials to promote post-infarction cardiac regeneration through gene therapy, a form of treatment that seeks to reactivate myocardial proliferation and repair mechanisms that are naturally inactivated after birth, thus preventing progression to failure. Several microRNA molecules (miRs) have demonstrated this ability in vivo in preclinical studies in large animals. However, advanced delivery strategies for miRs are required to overcome their biological instability, achieve their selective transport into cardiac cells and facilitate their translation into clinical medicine.

The main goal of DNABEATS is to create functionalised nanocarriers that deliver cardio-regenerative miRs selectively to damaged areas of the heart. Specifically, it is proposed to use DNA nanotechnology to build DNA-based nanocarriers (DNCs) that outperform other nanosystems used in gene therapy in terms of reproducible yield, biodegradability and simplicity to host large amount of miRs. The DNCs will be functionalised to achieve selective cardiac targeting and increase intracellular delivery of the miR.

The DNABEATS project consortium brings together established researchers from four European countries (Spain, Estonia, Lithuania and Poland) with expertise in complementary and synergistic scientific fields, including: DNA nanotechnology, nucleic acid delivery, cell signalling, proteomics, cardiac research, molecular and cell biology, and nanotoxicity. The team also has an interdisciplinary and transnational advisory board that will be key to broadening the impact of DNABEATS. In addition to Silvia Hernández Ainsa, ARAID researcher at the University of Zaragoza at INMA (CSIC-UNIZAR), who coordinates DNABEATS, the project has the following European partners: Laura Ordovás, ARAID researcher at the Instituto de Investigación Sanitaria Aragón (IIS Aragón), Margus Pooga from the University of Tartu (Estonia), Mindaugas Valius from the Vilnius University (Lithuania) and Monika Bzowska from the Jagiellonian University (Poland).

This news is part of the action PCI2023-143390 funded by MCIN/AEI/10.13039/501100011033 and co-funded by the European Union, being PCI2023-143390 the reference in the award resolution; MCIN the acronym of the Ministry of Science and Innovation; AEI the acronym of the State Research Agency; 10.13039/501100011033 the DOI (Digital Object Identifier) of the Agency”. DNBEATS was one of the projects selected in the Joint Call 2022 of the M-ERA.NET initiative, an international network co-funded by the European Commission through its Framework Programme for Research and Development (Horizon 2020, GA 958174) to support European research programmes in materials science and engineering.

Representative photo of the project

Silvia Hernández’s photo

 

15/09/2023

Previous Post

The Thermal Analysis Service obtains approval of its Quality Commitment Charter

Next Post

The 9th edition of “FEnanoMENOS” will involve 2,000 secondary and special education schoolchildren

Next Post
La IX edición de “FEnanoMENOS” implicará a 2.000 escolares de Secundaria y Educación Especial

The 9th edition of "FEnanoMENOS" will involve 2,000 secondary and special education schoolchildren

Últimas noticias destacadas

  • INMA researcher María José Martínez Pérez receives the 2025 National Research Award
  • 7 predoctoral contracts for doctoral training at INMA (the application period is now open)
  • INMA researcher María Sancho will investigate how to improve the efficacy of nanotherapies against metastasis.

Últimas publicaciones científicas destacadas

  • Core and end-Capped engineering as a powerful tool in the search of long-term high-performance dye-sensitized solar cells
  • Aragonese scientists make progress on a green alternative to the energy crisis
  • Large spin accumulation signals in ultrafast magneto-optical experiments

Últimas novedades

  • The MSCA-PF EMERGE project starts at INMA to advance cancer treatment with plant-derived extracellular vesicles
  • Aragon experiences a quantum autumn
  • 6th Call for Entries for the Best 2024-2025 Thesis Award

Últimas noticias de divulgación

  • From curiosity to play: Join Hi Score Science, send us your questions and dare to participate in our league
  • Populariser Sonia Fernández Vidal invites the people of Aragon to a “quantum coffee” at the Centro de Historias in Zaragoza
  • FenanoMENOS celebrates its tenth anniversary awakening scientific vocations in schoolchildren all over Spain

Bienvenida

  • Dr Cristina Momblona
  • Dr. Thomas S. van Zanten
  • Dr Cristina Bran

    Campus San Francisco, Facultad de Ciencias
    C/ Pedro Cerbuna, 12 – 50009 Zaragoza (España)

    Tel.:(+34) 876 55 33 22
    webmasterinma@unizar.es

    INSTITUTO DE NANOCIENCIA Y MATERIALES DE ARAGÓN, Copyright © 2022 INMA, CSIC-UZ | Aviso Legal | Política de cookies  | webmasterinma@unizar.es

    No Result
    View All Result
    • THE INSTITUTE
      • General information
        • Welcome
        • History of the Institute
        • Organizational chart
        • Departments
        • Scientific Committee
        • Annual Reports
        • Welcome Handbook
        • Associations
      • Directory
      • Location and contact
    • RESEARCH
      • Research Areas
        • Area 1: Materials for energy
          and environment (MEM)
        • Area 2: Materials for biomedicine (BIO)
        • Area 3: Materials for information
          technology (MTI)
        • Area 4: New phenomena at the
          nanoscale (NFN)
        • Area 5: Synthesis, processing and scaling
          of advanced functional materials (SPE)
        • Area 6: Singular experimental
          technologies (TES)
      • Research Groups
      • Scientific publications
      • International projects
      • INMA scientific infrastructure
      • Microdevices Engineering Technical Unit (UTIM)
        • Structure UTIM
        • Catalog UTIM
        • Applications UTIM
      • INMA large scientific facilities
    • TRAINING
      • Master NANOMAT
      • Degree studies
      • Master studies
      • PhD studies
      • Internships
      • Scholarships and grants
      • Course of introduction to laboratory safety -SegurINMA
      • Research career path in Spain
    • JOB OFFERS
    • DISSEMINATION
      • Activities
        • General public
        • Schools and institutes
        • Special events
        • Cátedra SAMCA de Nanotecnología (EN)
        • LMA
      • Projects
      • Advising and training
      • Awards and distinctions
      • Multimedia
    • TRANSFER
      • Technological offer
        • Patents
        • Capabilities for industry
      • Transferred technology
      • Spin-offs
    • EQUALITY
      • Protocols and prevention against harassment

    © 2025 JNews - Premium WordPress news & magazine theme by Jegtheme.

    Este sitio web utiliza cookies para que usted tenga la mejor experiencia de usuario. Si continúa navegando está dando su consentimiento para la aceptación de las mencionadas cookies y la aceptación de nuestra política de cookies

    ACEPTAR
    Aviso de cookies