En este estudio, un equipo liderado por Jesús del Barrio, investigador del Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-UNIZAR, explora el potencial de la calorimetría de valoración isotérmica como una potente herramienta para investigar la química covalente dinámica y los sistemas moleculares cooperativos.
Publicación científica:
Dissecting binary and ternary iminoboronate assemblies: A calorimetric study of thermodynamics, kinetics and allosteric effects
Journal of Organic Chemistry (2026), 15th Oct. 2026
Joseba Ruiz, Eduardo Laga, Adrián Velázquez-Campoy, Jesús del Barrio
Abstract: Dynamic covalent assemblies derived from ortho-boronoaldehydes, including iminoboronates and boronate esters, are key structural motifs in adaptive materials, chemical sensors, and reversible bioconjugation strategies. Herein, we report a label-free assay based on isothermal titration calorimetry that provides access to observed thermodynamic and model-derived kinetic parameters associated with assembly formation under defined experimental conditions. The assay further reveals cooperative binding between amine-based nucleophiles and diols toward ortho-boronoaldehyde derivatives, providing new insight into multicomponent dynamic covalent systems.
15-10-2026
